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10 bestCold Sore Medicationsof November 2025

112M consumers helped this year.

16% off

1

TYLENOL Extra Strength Cold eZ Tabs, Relieves Cold symptoms, Daytime and Nighttime, Convenience Pack, 40ct
TYLENOL Extra Strength Cold eZ Tabs, Relieves Cold symptoms, Daytime and Nighttime, Convenience Pack, 40ct

Tylenol

10.0

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30% off

2

Abreva Cream Tube Cold Sore Treatment, Heals your cold sore in 4.1 days*, Contains docosanol to protect healthy cells against the virus, 2 g
Abreva Cream Tube Cold Sore Treatment, Heals your cold sore in 4.1 days*, Contains docosanol to protect healthy cells against the virus, 2 g

Abreva

10.0

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3

Mederma Discreet Cold Sore Healing Patch - Twin Pack to Protect and Conceal Cold Sores (30 Patches)
Mederma Discreet Cold Sore Healing Patch - Twin Pack to Protect and Conceal Cold Sores (30 Patches)

Mederma

9.8

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10% off

4

Webber Naturals L-Lysine 1000 mg, 60 Tablets, Prevents Cold Sores, Vegan
Webber Naturals L-Lysine 1000 mg, 60 Tablets, Prevents Cold Sores, Vegan

Webber Naturals

9.6

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11% off

5

Renew Actives Fast-Acting L-Lysine 1000mg with Zinc & Vitamin C – Maximum Strength Cold Sore Relief & Herpes Simplex Virus (HSV) – Promotes Healthy Collagen Production for Hair, Skin & Nails – Easy to Swallow, Vegan, Made in Canada.
Renew Actives Fast-Acting L-Lysine 1000mg with Zinc & Vitamin C – Maximum Strength Cold Sore Relief & Herpes Simplex Virus (HSV) – Promotes Healthy Collagen Production for Hair, Skin & Nails – Easy to Swallow, Vegan, Made in Canada.

Renew Actives

9.3

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Related productsUp to 35% off

Pack of 2 x Quantum Lipclear Lysine and Cold Sore Treatment All Natural Ointment - 0.25 oz

Pack of 2 x Quantum Lipclear Lysine and Cold Sore Treatment All Natural Ointment - 0.25 oz

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Jamieson Cold Fighter Chewable - With Echinacea, Ginger, Vitamin C and Zinc, Gluten-Free, 30 Count (Pack of 1)

Jamieson Cold Fighter Chewable - With Echinacea, Ginger, Vitamin C and Zinc, Gluten-Free, 30 Count (Pack of 1)

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DocoShield Cold Sore Prevention Lip Balm w/Docosanol (3-Pack)

DocoShield Cold Sore Prevention Lip Balm w/Docosanol (3-Pack)

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Herstat Cold Sore Treatment - Clinically Proven to Treat Cold Sores Fast, 2g cream

Herstat Cold Sore Treatment - Clinically Proven to Treat Cold Sores Fast, 2g cream

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25% off

6

COLD-FX First Signs, Helps Relieve & Reduce Frequency, Severity & Duration of Cold and Flu Symptoms with North American Ginseng Extract, Echinacea, Andrographis & Zinc, 48 Vegan Capsules
COLD-FX First Signs, Helps Relieve & Reduce Frequency, Severity & Duration of Cold and Flu Symptoms with North American Ginseng Extract, Echinacea, Andrographis & Zinc, 48 Vegan Capsules

Cold-FX

9.1

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7

Compeed Cold Sore Patch - 15 Pack - Pack of 2
Compeed Cold Sore Patch - 15 Pack - Pack of 2

Compeed

8.8

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8

NeoCitran Cold & Sore Throat for Nighttime Relief, Lemon, 10 Count
NeoCitran Cold & Sore Throat for Nighttime Relief, Lemon, 10 Count

DOCLOGE

8.5

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14% off

9

Special Pack of 5 HERPECIN-L COLD SORE LIP BALM 0.1 oz
Special Pack of 5 HERPECIN-L COLD SORE LIP BALM 0.1 oz

Herpecin-L

8.3

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10

Dynamiclear Rapid Cold Sore Treatment, One-and-Done, All-Natural Single Application Topical One Dose Cold Sore Medication | Two applications per box | Licensed under NPN 80086208
Dynamiclear Rapid Cold Sore Treatment, One-and-Done, All-Natural Single Application Topical One Dose Cold Sore Medication | Two applications per box | Licensed under NPN 80086208

Dynamiclear Rapid

8.0

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