10 bestMethylfolate Supplementof December 2025
112M consumers helped this year.
1
Thorne Basic Prenatal - Folate Multivitamin for Pregnant and Lactating Women - 90 Capsules - 30 Servings
THORNE
9.7
2
Thorne Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules
THORNE
9.4
5% off
3
PUREFULLY 5-MTHF 1mg - Methylfolate (Active Form of Vitamin B9 Folate) Supplement - Supports Cardiovascular Health and Fetal Development - 90 Capsules
PUREFULLY
9.2
4
Pure Encapsulations MethylAssist 90's - B Vitamin Complex - Methylation Support* - Heart Health & Brain Health - Non-GMO & Gluten Free - 90 Capsules
Pure Encapsulations
8.9
5
Thorne 5-MTHF 1 mg Folate - Active Vitamin B9 Folate Supplement - 60 Capsules
THORNE
8.6
OtherUp to 10% off
Now Methyl Folate 1000mcg 90tab
AOR BioFolate 1mg Methylfolate 5-MTHF Plus B12 Supplement, 30 Capsules, Vegan & Gluten-Free, Active Vitamin B9 Folate for Men & Women, Pure Methyl B12 for Cardiovascular Support & Nutritional Wellness
Intelligent Labs 1MG 5-MTHF Methylfolate as Quatrefolic Acid®, 120 Veg Capsules, 4 Months Supply, MTHFR Supplement for Men & Women, 1MG=1000 mcg of Vitamin B9 Activated Folate for Methylation Support
Pure Folate 400mcg, Optimized Methylfolate, Clean Label, 180 Small Tablets, Lab Verified, Vegan & Hypoallergenic, Supplement for Men & Women, Pregnancy, Mood, & Heart Health, by Igennus
6
Designs for Health L-5-MTHF Folate, 5mg (8500mcg DFE) - Quatrefolic Active Vitamin B9 Methylfolate Supplement, 5000mcg - Non-GMO, Gluten Free (60 Capsules)
designs for health
8.4
7
Pure Encapsulations Folate 1000 - Metafolin L-5-MTHF - Folate Supplement - Non-GMO & Gluten Free - 90 Capsules
Pure Encapsulations
8.1
8
Pure Encapsulations B12 Folate - Energy Supplement to Support Nerves, Energy Metabolism & Cognitive Support* - With Vitamin B Folate as Metafolin - 60 Capsules
Pure Encapsulations
7.8
28% off
9
Super B Complex - High Absorption Methylated B Vitamins, Methyl B12, Methyl Folate, Vitamin B6 & Vitamin C, Sustained Release, Flush-Free Niacin, 60 Tablets, By Igennus
Igennus Healthcare Nutrition
7.5
10
Genestra Brands Active Folate 1000-1000 mcg Folate Supplement - Fetal Health Support - B Vitamin - Vegan, Dairy Free & Gluten Free - 90 Vegetarian Capsules
Genestra Brands
7.2
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A Guide to Selecting the Best Methylfolate Supplement
Choosing the right methylfolate supplement can make a big difference in supporting your health, especially if you have specific needs related to folate metabolism. Methylfolate is the active form of folate, a B-vitamin that plays a crucial role in cell growth, DNA production, and overall well-being. When shopping for a methylfolate supplement, it's important to understand the key features that can affect how well the supplement works for you and how it fits into your daily routine.
Dosage (Amount per Serving)
Dosage refers to the amount of methylfolate provided in each serving of the supplement, usually measured in micrograms (mcg) or milligrams (mg). This is important because your body’s needs can vary depending on your age, health status, and whether you have a medical condition that affects folate metabolism. Lower dosages (such as 400-800 mcg) are often suitable for general health and daily maintenance, while higher dosages (1 mg or more) may be recommended for people with specific medical needs, such as those with certain genetic variations. To pick the right dosage, consider your health goals and, if possible, consult with a healthcare provider to determine what’s best for you.
Form of Methylfolate
The form of methylfolate refers to the specific chemical structure used in the supplement, with L-methylfolate (often listed as 5-MTHF or L-5-methyltetrahydrofolate) being the most bioavailable and active form. This is important because some people have trouble converting regular folic acid into its active form, so choosing a supplement that provides methylfolate directly ensures better absorption and effectiveness. When comparing products, look for those that specify L-methylfolate or 5-MTHF, as these are generally considered the most effective for most people.
Purity and Additives
Purity refers to how clean the supplement is, meaning it contains mostly methylfolate without unnecessary fillers, artificial colors, or preservatives. This is important because some people may be sensitive to certain additives, or may want to avoid allergens like gluten, soy, or dairy. When choosing a supplement, check the ingredient list for any unwanted extras and opt for products that are labeled as free from common allergens or unnecessary additives if you have sensitivities or prefer a cleaner product.
Delivery Form (Tablet, Capsule, Liquid, etc.)
The delivery form is how the supplement is taken, such as tablets, capsules, liquids, or even chewables. This matters because some people have difficulty swallowing pills, while others may prefer a liquid or chewable option for convenience or better absorption. To choose the right form, think about your personal preferences and any physical needs you may have, such as ease of swallowing or taste.
Third-Party Testing and Certifications
Third-party testing means the supplement has been checked by an independent organization for quality, purity, and accuracy of labeling. Certifications can include things like GMP (Good Manufacturing Practices), NSF, or USP. This is important because it gives you confidence that you’re getting what the label claims, without harmful contaminants. If quality assurance is important to you, look for supplements that mention third-party testing or carry reputable certifications.
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