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10 bestEnzyme Drain Cleanerof December 2025

112M consumers helped this year.

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Septic Tank System Treatment Pods - 12 Dissolving Packets | Enzyme-Producing Live Bacteria Solution | 1 Year Supply Professional Eco-Friendly Maintenance | Prevent Clogs, Odor & Backups | Made in USA
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1

Green Gobbler Drain Clog Remover & Cleaner, For Toilets, Sinks, Tubs - Septic Safe, 2 Pack
Green Gobbler Drain Clog Remover & Cleaner, For Toilets, Sinks, Tubs - Septic Safe, 2 Pack

Green Gobbler

9.9

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2

Bio-clean Drain Septic Bacteria (2 lb.) (Packaging may vary)
Bio-clean Drain Septic Bacteria (2 lb.) (Packaging may vary)

Bio-Clean

9.8

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3

Green Gobbler Main Line Drain Opener & Toilet Clog Remover, Odorless Formula, Septic Safe Hair Clog Remover, 128 Oz
Green Gobbler Main Line Drain Opener & Toilet Clog Remover, Odorless Formula, Septic Safe Hair Clog Remover, 128 Oz

Green Gobbler

9.7

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4

Green Gobbler Septic Saver | Septic Tank Treatment Packets | 2 Pack | 1 Year Septic Tank Supply
Green Gobbler Septic Saver | Septic Tank Treatment Packets | 2 Pack | 1 Year Septic Tank Supply

Green Gobbler

9.5

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5

Drano Max Gel Drain Clog Remover and Cleaner, Unclogs and Removes Blockages from Showers and Sinks, 2.3L
Drano Max Gel Drain Clog Remover and Cleaner, Unclogs and Removes Blockages from Showers and Sinks, 2.3L

DRANO

9.3

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Septic Tank System Treatment Pods - 12 Dissolving Packets | Enzyme-Producing Live Bacteria Solution | 1 Year Supply Professional Eco-Friendly Maintenance | Prevent Clogs, Odor & Backups | Made in USA

Septic Tank System Treatment Pods - 12 Dissolving Packets | Enzyme-Producing Live Bacteria Solution | 1 Year Supply Professional Eco-Friendly Maintenance | Prevent Clogs, Odor & Backups | Made in USA

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FlyZyme | Ultra-Strength Drain Enzyme Gel | Drain & Fruit FlyZyme Eliminator | Highly Concentrated Enzyme Cleaner & Treatment | Eco-Friendly & Safe for Pipes (1 Gal)

FlyZyme | Ultra-Strength Drain Enzyme Gel | Drain & Fruit FlyZyme Eliminator | Highly Concentrated Enzyme Cleaner & Treatment | Eco-Friendly & Safe for Pipes (1 Gal)

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Fruit Fly Drain Cleaner/Treatment | Eliminate Sink Solution | All-Natural Cleaner | Non-Toxic | Works Fast to Open Drain & Against All Types of Gnats & Drain Flies (32 oz/Pack of 1)

Fruit Fly Drain Cleaner/Treatment | Eliminate Sink Solution | All-Natural Cleaner | Non-Toxic | Works Fast to Open Drain & Against All Types of Gnats & Drain Flies (32 oz/Pack of 1)

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Bio-Clean Ultimate Drain Cleaning Kit Cleans Drains- Septic Tanks - Grease Traps All Natural and 100% Guaranteed No Caustic Chemicals! Removes fats oil and grease, completely cleans your system.

Bio-Clean Ultimate Drain Cleaning Kit Cleans Drains- Septic Tanks - Grease Traps All Natural and 100% Guaranteed No Caustic Chemicals! Removes fats oil and grease, completely cleans your system.

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6

Green Gobbler Fresh Scent Drain Cleaner & Deodorizer Sticks- Prevents Sink & Shower Drain Clogs, Prevents Odors, Septic-Safe - 8 Count (2 PACK)
Green Gobbler Fresh Scent Drain Cleaner & Deodorizer Sticks- Prevents Sink & Shower Drain Clogs, Prevents Odors, Septic-Safe - 8 Count (2 PACK)

Green Gobbler

9.1

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7

DSCover Odor Eliminator Bio Culture 3.78L, Biological Enzymes for Odor Control Cleaner in Septic Tanks, RVs, Drains, Garbage Containers, Pet Urine, Cat litter, Sports Equipment, Made in Canada
DSCover Odor Eliminator Bio Culture 3.78L, Biological Enzymes for Odor Control Cleaner in Septic Tanks, RVs, Drains, Garbage Containers, Pet Urine, Cat litter, Sports Equipment, Made in Canada

DSCOVER

8.9

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8

Probiotic Enzyme Cleaner - Professional Strength Solution -One Gallon- Natural Bio-Enzymatic Stain & Odor Remover - No Rinse Formula - Dye Free (Packaging May Vary)
Probiotic Enzyme Cleaner - Professional Strength Solution -One Gallon- Natural Bio-Enzymatic Stain & Odor Remover - No Rinse Formula - Dye Free (Packaging May Vary)

Bastion

8.6

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9

Green Gobbler Hair Grabber Drain Snake - 5 Pack (Great for Sink & Shower Clogs)
Green Gobbler Hair Grabber Drain Snake - 5 Pack (Great for Sink & Shower Clogs)

Green Gobbler

8.4

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6% off

10

Roebic K-570-Q Biodegradable Leach and Drain Field Treatment Concentrate Environmentally Friendly Bacteria Enzymes Treat Septic Clogs & Buildup, 32 Ounces
Roebic K-570-Q Biodegradable Leach and Drain Field Treatment Concentrate Environmentally Friendly Bacteria Enzymes Treat Septic Clogs & Buildup, 32 Ounces

Roebic

8.2

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