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10 bestCat Urine Enzymatic Cleanerof June 2025

112M consumers helped this year.

1

Angry Orange Pet Odor Eliminator for Home - 8oz Dog and Cat Pee Smell Remover for Carpet, Grass, Tile and Furniture - Citrus Concentrate, Makes 128oz of Liquid
Angry Orange Pet Odor Eliminator for Home - 8oz Dog and Cat Pee Smell Remover for Carpet, Grass, Tile and Furniture - Citrus Concentrate, Makes 128oz of Liquid

ANGRY ORANGE

Editor’s Choice

9.9

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2

Eco Strong Pet Stain and Odor Remover - Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner - 128 Oz
Eco Strong Pet Stain and Odor Remover - Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner - 128 Oz

Eco Strong

9.8

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3

ez-clean Advanced Odor Remover- Highly Concentrated Bio Enzyme Pet Odor Eliminator for Dog, Cat, and Small Animal Urine Indoor & Outdoor Use for Any Organic Spills(1 L (Pack of 1))
ez-clean Advanced Odor Remover- Highly Concentrated Bio Enzyme Pet Odor Eliminator for Dog, Cat, and Small Animal Urine Indoor & Outdoor Use for Any Organic Spills(1 L (Pack of 1))

ez-clean

9.7

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4

Nature's Miracle JFC Advanced Stain & Odor Remover - 32oz Trigger
Nature's Miracle JFC Advanced Stain & Odor Remover - 32oz Trigger

Nature's Miracle

9.6

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5

Orange Odor Eliminator | Pet Odor Deodorizer for Strong Odor | Enzyme Stain Cleaner for Cats, Dogs, and Pets | Great for Carpets, Furniture, Dog Kennels, and More… (32 Oz)
Orange Odor Eliminator | Pet Odor Deodorizer for Strong Odor | Enzyme Stain Cleaner for Cats, Dogs, and Pets | Great for Carpets, Furniture, Dog Kennels, and More… (32 Oz)

Eco Strong

9.3

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6

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz
Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz

Nature's Miracle

9.0

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7

Nature's Miracle Stain and Odor Remover Cat, Odor Control Formula, Pour
Nature's Miracle Stain and Odor Remover Cat, Odor Control Formula, Pour

Nature's Miracle

8.7

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8

Simple Green Cat Stain & Odor Remover - Enzyme Cleaner for Cat Urine, Feces, Blood, Vomit (32 oz Sprayer & 1 Gallon Refill)
Simple Green Cat Stain & Odor Remover - Enzyme Cleaner for Cat Urine, Feces, Blood, Vomit (32 oz Sprayer & 1 Gallon Refill)

SIMPLE GREEN

8.5

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9

Professional Strength Stain & Odor Eliminator - Enzyme-Powered Pet Odor & Stain Remover for Dogs and Cat Urine - Spot Carpet Cleaner - Small Animal Odor Remover (32 oz)
Professional Strength Stain & Odor Eliminator - Enzyme-Powered Pet Odor & Stain Remover for Dogs and Cat Urine - Spot Carpet Cleaner - Small Animal Odor Remover (32 oz)

Rocco & Roxie Supply Co

8.2

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7% off

10

Cat Stain and Odor Remover| Enzyme Urine Odor Neutralizer - Stain Remover for Carpet, Litter Boxes, Bedding, and Laundry [Citrus Scent Gallon Value Size]
Cat Stain and Odor Remover| Enzyme Urine Odor Neutralizer - Stain Remover for Carpet, Litter Boxes, Bedding, and Laundry [Citrus Scent Gallon Value Size]

Eco Strong

7.9

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A Guide to Selecting the Best Cat Urine Enzymatic Cleaner

Choosing the right cat urine enzymatic cleaner can make a big difference in keeping your home fresh and free from lingering odors. These cleaners use special enzymes to break down the proteins in cat urine, which helps eliminate both the smell and the stain. When shopping for one, it's important to look beyond just the label and understand what makes a cleaner effective for your specific needs. Consider where you'll be using it, how sensitive your household is to chemicals or fragrances, and how persistent the stains or odors are. By focusing on a few key features, you can find a cleaner that works best for your home and your cat.

Enzyme Type

The enzyme type refers to the specific biological agents used in the cleaner to break down urine molecules. This is important because different enzymes target different components of urine, such as proteins, starches, or fats. Most cat urine cleaners use protease enzymes, which are effective at breaking down the proteins in urine that cause odor. Some products may combine multiple enzyme types for broader cleaning power. If you have persistent or old stains, a cleaner with a mix of enzymes may be more effective. For fresh stains, a single-enzyme cleaner can often do the job. Consider the age and severity of the stains in your home when choosing the enzyme type.

Surface Compatibility

Surface compatibility means which materials the cleaner is safe to use on, such as carpets, hardwood floors, upholstery, or tile. This is important because some cleaners can damage certain surfaces or leave residues. Cleaners are usually labeled for use on specific surfaces, so check the packaging or product description. If you need a cleaner for multiple areas, look for one that is marked as multi-surface. If you have delicate fabrics or specialty flooring, make sure the cleaner is safe for those materials. Always test a small, hidden area first to ensure there is no discoloration or damage.

Odor Neutralization

Odor neutralization refers to how well the cleaner removes or masks the smell of cat urine. This is crucial because cats may return to the same spot if they can still smell their scent. Some cleaners use added fragrances to mask odors, while others rely solely on enzymes to eliminate the source of the smell. If you or your household members are sensitive to scents, look for a fragrance-free or low-scent option. If you prefer a fresh-smelling home, a cleaner with a light, pleasant fragrance may be a good fit. The best choice depends on your sensitivity to smells and your preference for scented or unscented products.

Drying Time

Drying time is how long it takes for the cleaner to work and for the treated area to dry completely. This matters because a longer drying time can mean the area is out of use for a while, and some cleaners need to stay wet to be effective. Quick-drying formulas are convenient for busy households or high-traffic areas. If you can leave the area undisturbed, a longer-acting cleaner may provide deeper cleaning. Think about how quickly you need the area back in use and whether you can keep pets and people away during the drying process.

Safety for Pets and Children

Safety for pets and children means the cleaner does not contain harmful chemicals or residues that could be dangerous if touched or ingested. This is especially important in homes with young children or multiple pets. Look for cleaners labeled as non-toxic, biodegradable, or safe for use around pets and kids. If you have animals that like to lick or chew surfaces, this feature is even more important. Always follow the instructions for use and storage to ensure safety in your home.

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